Sep 02, 2011 we use your linkedin profile and activity data to personalize ads and to show you more relevant ads. Trematodes flukes opisthorchis viverrini southeast asian liver fluke and opisthorchis felineus cat liver fluke. Opisthorchis viverrini and opisthorchis felineus, also called the southeast asian liver fluke and. We report 2 outbreaks of opisthorchis felineus infection caused by the consumption of tench filets tinca tinca from a lake in italy. Opisthorchis felineus small biliary fluke, causing opisthorchiasis. Additionally, cysts containing the parasite can sometimes be detected by ultrasound, ct, or. Opisthorchis viverrini and clonorchis sinensis are liver flukes a type of flatworm that. Opisthorchiasis is a parasitic disease caused by species in the genus opisthorchis specifically, opisthorchis viverrini and opisthorchis felineus. Epidemiology of opisthorchis viverrini in an endemic area. We use your linkedin profile and activity data to personalize ads and to show you more relevant ads. If you have problems viewing pdf files, download the latest version of adobe reader.
Moreover, specific amplification was also achieved by the use of fecal. This chronic disease is associated with hepatobiliary inflammation, cholangiocyte dysplasia, cholangiofibrosis, intraepithelial neoplasia, and even cholangiocarcinoma among chronically infected individuals. Phylogenetic analysis revealed an almost equal distance between o. The acta2 gene data are normalized to gene hprt1, the tgf.
Opisthorchis felineus has a complex life cycle involving three hosts. The fda recommends the following for fish preparation or storage to kill any parasites. Chromosomal disarrangement and immunoreactivity of golden. Fish intermediate hosts of the liver flukes a opisthorchis viverrini.
The term fluke means flatfish, since these parasites are flat. They have a knob at the abopercular end that may be prominent, inconspicuous, or absent. Opisthorchis felineus infection provokes timedependent. The purpose of the present study was to determine the complete mitochondrial dna sequence of this flatworm. It hitches a ride with an intermediate host, typically the land snail, which is then ingested by another intermediate host, such as. The main sources of the disease are infected persons and animals, whose feces carry the parasites eggs to water. Genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126 tollfree. Because of its relatively low conservation, the pm gene may be a convenient genetic marker for studying phylogenetic. The foodborne liver fluke opisthorchis felineus is an epidemiologically important species and the causative agent of opisthorchiasis across an. Endemicity of for species identification of opisthorchis o. Hemozoin knobs in opisthorchis felineus infected liver. Expression of key genes of fibrogenesis in syrian hamsters during chronic opisthorchiasis. Opisthorchiasis is prevalent in western siberia and in the region of the dnieper. Opisthorchis felineus, or cat liver fluke is a trematode parasite that infects the liver in mammals.
Pdf opisthorchis viverrini and opisthorchis felineus researchgate. They need to be ingested by freshwater gastropod snail, the first intermediate host, to develop into sporocysts, rediae, and freeswimming cercariae, the stage infective for the second intermediate host, cyprinoid fish 3, 7. An integrated epidemiological study of opisthorchis viverrini consisting of risk factors analysis and parasitation prevalence determination in humans, as well as the assessment the roles of host reservoirs dogs and cats and intermediate hosts cyprinid fish was carried out in the vicinity of huay luang dam, udon thani province, in the north east of thailand. These liver flukes are known to cause serious human diseases affecting bile ducts and the gall bladder. The liver fluke infection in thailand was caused by o. By the end of the 19th century, distoma contained so many species that blanchard introduced the genus opisthorchis for elongated flat flukes with testes in the posterior end of the body.
Pdf opisthorchis viverrini and opisthorchis felineus. It was first discovered in 1884 in a cats liver by sebastiano rivolta of italy. Opisthorchis infection does not result from drinking river water or other nonpotable water. The human liver fluke, opisthorchis viverrini sensu lato s. Opisthorchis felineus 20200510 20200510 tagged medical chemical corporation.
In 1891, russian parasitologist, konstantin nikolaevich vinogradov 18471906 found it in a human, and named the parasite a siberian liver fluke. The cat liver fluke, also known as opisthorchis felineus, is a trematode parasite that lives in water. Parasite liver and biliary tree parasites 69 cdc dpdx opisthorchiasis liver and biliary tree parasites 69 liver and biliary tree parasites 69. A high prevalence has been reported in byelorussia, russia, and the ukraine. It is known to cause a significant health burden in the opisthorchiasis region in thailand and possibly throughout mainland southeast. Since then, cases of opisthorchiasis were reported each year. Opisthorchiasis is generally known as cat liver fluke disease, if it is caused by o. Plasma metabolomics of the time resolved response to. Opisthorchis viverrini poirier 1886 poirier 1886 encyclopedia. For language access assistance, contact the ncats public information officer.
The tumorigenic liver fluke opisthorchis viverrini multiple. Examination of faeces and duodenal secretion discovered eggs of opisthorchis felineus, a liver fluke especially common. Infeetion with livr flukes opisthorchis viverrini, opisthorchis felineus and clonorchis sinensis 1. Opisthorchis felineus and metorchis bilis metacercariae in. Worldwide, the number of cases of human infection has been estimated to be 1.
Pdf investigation on opisthorchis felineus occurrence and. Clinical signs are variable, and infestation with a moderate number of. A study of tribendimidine effects in vitro and in vivo on the liver fluke. Opisthorchiasis caused by opisthorchis viverrini o. Opisthorchiasis is a hepatobiliary disease caused by flukes of the trematode family opisthorchiidae. Infections with the opisthorchid liver flukes clonorchis sinensis, opisthorchis viverrini, and o. We investigated the immune activities of an immortalized murine dendritic cell mdc line jawsii and of primary human dendritic. Medical care and loss of wages caused by opisthorchis viverrini in laos and. Experimental and modelling investigations of opisthorchis. The purpose of the present study was to determine the.
Chronic infection may lead to cholangiocarcinoma, a malignant cancer of the bile ducts. Feline liver fluke worm is a killer feline instincts. Pdf the liver fluke opisthorchis felineus is a member of the triad of. The international agency for research on cancer classifies the infection with the liver flukes opisthorchis viverrini and. The infection is associated with a number of hepatobiliary diseases, including cholangitis, obstructive jaundice, hepatomegaly, cholecystitis, cholelithiasis and cholangiocarcinoma.
Opisthorchis felineus life cycle pixelmasterdesign. The adult flukes deposit fully developed eggs that are passed in the feces. Epidemiology of opisthorchis viverrini in an endemic area of. The opisthorchis viverrini genome provides insights into life in. In 1927, prommas identified the worms found at an autopsy of a 17yearold thai male residing in roiet, northeast thailand, as o. Opisthorchiasis is widespread in russia, especially western siberia. A significant difference as compared with the control group p values 05. The life cycle and parasitic system of opisthorchis felineus in the. Opisthorchiasis genetic and rare diseases information. Parasite liver and biliary tree parasites 69 cdc dpdx opisthorchiasis.
Proteins and other mediators released from parasitic worms exert cogent downmodulation of atopic and other allergic reactivity. Opisthorchis infection can be prevented by avoiding raw or undercooked freshwater fish. Human illnesses caused by opisthorchis felineus flukes, italy. Pdf investigation on opisthorchis felineus occurrence. There is a general, inverse relationship between helminth infection and allergic diseases including bronchial asthma ba. Human illnesses caused by opisthorchis felineus flukes. Hemozoin from the liver fluke, opisthorchis felineus. It is also present in puerto rico and possibly other caribbean islands.
Together they affect more than 45 million people and 600750 million people are at risk in the endemic regions of eurasia. Infection of the definitive host follows the consumption of fish contaminated with metacercariae. It demonstrates high diagnostic and therapeutic potential. To reduce this health burden, a comprehensive prevention and control. The cdna sequence of opisthorchis felineus paramyosin pm was determined and shown to have 6670% homology with two schistosomes and two cestodes. The liver fluke opisthorchis felineus is a member of the triad of epidemiologically relevant species of the trematode family opisthorchiidae, and the causative agent of opisthorchiasis felinea over an extensive range that spans regions of eurasia.
Opisthorchis felineus an overview sciencedirect topics. Opisthorchis felineus article about opisthorchis felineus. Opisthorchis felineus infection provokes timedependent accumulation of. In this work the formation of cocalled hemozoin knobs the bile duct ectasia filled up by hemozoin pigment in opisthorhis felineus infected hamster liver has been observed. Foodborne trematodiasis fbt is a significant global health problem, with the liver flukes opisthorchis viverrini, o.
The eggs are shed in the biliary tree of fisheating mammals and are passed with feces. Infection with opisthorchis felineus induces intraepithelial. May first report and molecular identification of opisthorchis viverrini infection in human communities from lower myanmar win pa pa aung 0 1 2 thi thi htoon 0 2 htay htay tin 0 2 kyi kyi thinn 0 2 oranuch sanpool 0 1 2 jurairat jongthawin 0 1 2 lakkhana sadaow 0 1 2 issarapong phosuk 0 1 2 rutchanee rodpai 0 1 2 pewpan m. Opisthorchis felineus rivolta, 1884 is a member of the triad of epidemiologically important fishborne liver trematodes, which also includes o. The tumorigenic liver fluke opisthorchis viverrini. Opisthorchis felineus life cycle home opisthorchis felineus life cycle 20200511 20200511 tagged life cycle of opisthorchis viverrini. Domestic animals, especially cats, become infected by eating insufficiently cooked fish. Lightly salted, smoked, or pickled fish can contain infectious parasites. Investigation on opisthorchis felineus occurrence and life cycle in italy article pdf available in veterinary parasitology 17712. All structured data from the file and property namespaces is available under the creative. When present, symptoms fever, nausea, abdominal pain, and myalgias were mild.
Liver fluke infection is recognized as the major risk factor of cholangiocarcinoma. Early identification of the infection is essential to provide timely and appropriate chemotherapy to patients. Characteristics of liver fibrosis associated with chronic. The eggs of opisthorchis are very similar to those of clonorchis, another liver fluke, but can be distinguished by microscopic features. Opisthorchis felineus wikipedia, a enciclopedia livre. Opisthorchiasis is an infection caused by either of the two parasite worms, the cat liver fluke, or scientifically called opisthorchis felineus also known as opisthorchis tenuicollis, or the southeast asian liver fluke called as opisthorchis viverrini. Molecular identification of clonorchis sinensis and. He chose rivoltas opisthorchis felineus as the type species. It hitches a ride with an intermediate host, typically the land snail, which is then ingested by another intermediate host, such as the lizard and frog. Opisthorchis felineus, a hepatic trematode, is the causative agent of opisthorchiasis, a dangerous disease in both human beings and animals. Opisthorchiasis is a parasitic disease caused by species in the genus opisthorchis chronic infection may lead to cholangiocarcinoma, a malignant cancer of the bile ducts. Media in category opisthorchis the following 2 files are in this category, out of 2 total. Opisthorchis felineus is a trematode that is transmitted to humans through the consumption of raw freshwater fish of the family cyprinidae. The causative agent, the siberian liver fluke opisthorchis felineus, infests the liver, gallbladder, and pancreas of man, cats, and dogs.
Hemozoin is the pigment produced by some bloodfeeding parasites. Similar to bile duct cancer or cholangiocarcinoma cca in the western world, opisthorchiasisassociated cca in southeast asia is an aggressive cancer with high mortality rates. Diagnosis of opisthorchis infection is based on microscopic identification of eggs in stool specimens. Histological analysis of the liver of uninfected hamster control. Complete sequencing of the mitochondrial genome of. Opisthorchis felineus cat liver fluke is commonly found in eastern europe and russia. We investigated the immune activities of an immortalized murine dendritic cell mdc line jawsii and of primary human dendritic cells. Chromosomal disarrangement and immunoreactivity of golden hamsters infected with opisthorchis felineus. Liver fluke infection with opisthorchis viverrini, opisthorchis felineus and clonorchis sinensis remains a major public health problem in many parts of asia and eastern europe. In the 1930s, helminthologist hans vogel of hamburg published an. Macrophotograph of the liver of uninfected hamster control at a 5, b 24 and c 48 weeks after the start of the experiment. Opisthorchiasis caused by foodborne trematode opisthorchis felineus is a substantial public health problem, with 17 million persons infected worldwide. More than one stool sample may be needed to detect the eggs. The mlpa products could be successfully detected using a capillary sequencer figure 5.
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